Saturday, January 13, 2007

Common cold virus may be new weapon to fight cancer

A good news story for a change - doubly so because it's from gene therapy. Leonard Seymour, based at Oxford University and president of the British Society for Gene Therapy, is leading work on using viruses to kill cancer cells, a completely new way to tackle the disease. When the human genome project was completed a few years ago, people thought that biologists would be able to play with genes immediately and we would usher in a new world of treatments and understanding of disease. Gene therapy, as it was called, would be our saviour.

It was all a touch overblown (much of it media hype to be honest) and it's taking a bit longer than expected but that doesn't take away from the value of the emerging research. Expect to see more from the gene therapists in the coming years.

To put Prof Seymour's work into a bit more context with other cancer treatments, I posted on the Guardian's Comment is Free blog about whether this was "the" cure for cancer.

Common cold virus may be new weapon to fight cancer

· Human trials begin this year
· Scientists say move is 'exciting'

Thursday January 11, 2007
The Guardian

The adenovirus is one of two cold viruses likely to be examined in the first trials.

British scientists are preparing to launch trials of a radical new way to fight cancer, which kills tumours by infecting them with viruses like the common cold.

If successful, virus therapy could eventually form a third pillar alongside radiotherapy and chemotherapy in the standard arsenal against cancer, while avoiding some of the debilitating side-effects.

Leonard Seymour, a professor of gene therapy at Oxford University, who has been working on the virus therapy with colleagues in London and the US, will lead the trials later this year. Cancer Research UK said yesterday that it was excited by the potential of Prof Seymour's pioneering techniques.

Article continues
One of the country's leading geneticists, Prof Seymour has been working with viruses that kill cancer cells directly, while avoiding harm to healthy tissue. "In principle, you've got something which could be many times more effective than regular chemotherapy," he said.

Cancer-killing viruses exploit the fact that cancer cells suppress the body's local immune system. "If a cancer doesn't do that, the immune system wipes it out. If you can get a virus into a tumour, viruses find them a very good place to be because there's no immune system to stop them replicating. You can regard it as the cancer's Achilles' heel."

Only a small amount of the virus needs to get to the cancer. "They replicate, you get a million copies in each cell and the cell bursts and they infect the tumour cells adjacent and repeat the process," said Prof Seymour.

Preliminary research on mice shows that the viruses work well on tumours resistant to standard cancer drugs. "It's an interesting possibility that they may have an advantage in killing drug-resistant tumours, which could be quite different to anything we've had before."

Researchers have known for some time that viruses can kill tumour cells and some aspects of the work have already been published in scientific journals. American scientists have previously injected viruses directly into tumours but this technique will not work if the cancer is inaccessible or has spread throughout the body.

Prof Seymour's innovative solution is to mask the virus from the body's immune system, effectively allowing the viruses to do what chemotherapy drugs do - spread through the blood and reach tumours wherever they are. The big hurdle has always been to find a way to deliver viruses to tumours via the bloodstream without the body's immune system destroying them on the way.

"What we've done is make chemical modifications to the virus to put a polymer coat around it - it's a stealth virus when you inject it," he said.

After the stealth virus infects the tumour, it replicates, but the copies do not have the chemical modifications. If they escape from the tumour, the copies will be quickly recognised and mopped up by the body's immune system.

The therapy would be especially useful for secondary cancers, called metastases, which sometimes spread around the body after the first tumour appears. "There's an awful statistic of patients in the west ... with malignant cancers; 75% of them go on to die from metastases," said Prof Seymour.

Two viruses are likely to be examined in the first clinical trials: adenovirus, which normally causes a cold-like illness, and vaccinia, which causes cowpox and is also used in the vaccine against smallpox. For safety reasons, both will be disabled to make them less pathogenic in the trial, but Prof Seymour said he eventually hopes to use natural viruses.

The first trials will use uncoated adenovirus and vaccinia and will be delivered locally to liver tumours, in order to establish whether the treatment is safe in humans and what dose of virus will be needed. Several more years of trials will be needed, eventually also on the polymer-coated viruses, before the therapy can be considered for use in the NHS. Though the approach will be examined at first for cancers that do not respond to conventional treatments, Prof Seymour hopes that one day it might be applied to all cancers.

Richard Sullivan, Cancer Research UK's director of clinical programmes, said: "We are pleased to be supporting this new and important research. Whilst this approach is still at an early stage of development it has exciting potential, particularly for the treatment of cancer which has spread, a notoriously difficult stage of the disease to treat."

1 comment:

anna mcgarrigle said...

how does one get in touch with Leonard Seymour? is it possible

my sister who is 60 yrs old was recently diagnosed with clear cell sarcoma, primary tumour small intestine removed in aug. but it had metastasized to liver and surrounding lymph nodes..
she's had one liver resection and a portal vein embolization to promote growth in the one unaffected part of organ, directly in middle. she awaits 2nd embo. the big lobe is to be removed when the liver has regenerated to an acceptable size. otherwise she is a very healthy woman, exercizes regularly and looks great.
there is no treatment for this kind of sarcoma just surgery when possible. i know this is probably a long shot but you may know how to reach this Dr. Seymour or his organization.he may be looking for a rare woman with a rare form of cancer. we live in Montreal, Canada.


anna mcgarrigle one half of singing duo Kate and Anna McGarrigle.